Mozifor 24mg Injection (Plerixafor)
Prescription RequiredManufactured By
Hetero Drugs LTD
Pack Of
1
Salt Composition
Plerixafor
Storage
Keep in cold place
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ALL SUBSTITUTES
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Overview
Mozifor 24mg Injection (Plerixafor) is a prescription oncology-based anticancer medication which is used to mobilize hematopoietic stem cells from the bone marrow into the bloodstream. It contains plerixafor as an active salt composition, which belongs to the drug class of Hematopoietic stem cell mobilizers. The medicine works by blocking the CXCR4 receptor that normally holds stem cells in the bone marrow. By blocking this receptor, the medicine releases stem cells into the blood stream and makes the treatment easier to collect for transplantation.
The injection is administered subcutaneously by a qualified doctor several hours before the stem cell collection in a hospital or clinical setting. Treatment is usually given after the patient has received a G-CSF medicine for several days. The doctor determines the dosage of the Plerixafor 24mg injection according to the treatment regimen, age, and overall health of the patient. It should not be self-administered. Patients are advised not to change the dosage and timings prescribed by the doctors because it can cause severe side effects.
Common side effects include diarrhea, nausea, vomiting, abdominal discomfort, headache, dizziness, fatigue, joint pain, and injection-site reactions. A few patients can undergo severe side effects, including severe allergic reactions, changes in blood cell counts, and enlargement or rupture of the spleen. Most of the plerixafor 24mg injection side effects can leave when the body adapts to the medicine. However, if any side effects persist, inform your doctor immediately.
The medicine may cause fetal harm, so women who can become pregnant must use effective contraception during treatment. Breastfeeding is not recommended during treatment and for one week after the final dose. Patients must list all medicines, supplements, and herbal products that they are taking. The plerixafor 24mg injection must be used under medical oversight or medical supervision only. Attend regular tests and follow-ups to monitor the medicine response and reduce side effects. Before making any adjustments, changing the dose, or stopping the treatment, consult with your doctor to maximize the benefit.
Indication
Blood Cancer
Side Effects
As with any medication, some people may experience adverse side effects while taking Plerixafor 24mg Injection (Mozifor). Most of these are mild and tend to resolve on their own as the body adjusts to the treatment. However, it is important to monitor the symptoms and seek medical advice if needed:
● Diarrhea
● Redness or irritation in the injection site
● Low RBC count
● Constipation, indigestion
● Dry mouth, numbness
● Joint pains
● Sweating
● Difficulty in sleeping
● Headache
How To Use
Mozifor 24mg Injection (Plerixafor) is given subcutaneously (under the skin). The injection is usually administered 6–11 hours before stem cell collection to help mobilize stem cells from the bone marrow into the bloodstream for harvesting.
Dose is based on the weight and medical condition of a patient. Follow the instructions carefully given the healthcare professional.
Reference
● DiPersio, J. F., Uy, G. L., Yasothan, U., & Kirkpatrick, P. (2009). Plerixafor. Nature reviews Drug discovery, 8(2), 105-107.
● Fricker, S. P. (2013). Physiology and pharmacology of plerixafor. Transfusion Medicine and Hemotherapy, 40(4), 237-245.
● De Clercq, E. (2019). Mozobil®(Plerixafor, AMD3100), 10 years after its approval by the US Food and Drug Administration. Antiviral Chemistry and Chemotherapy, 27, 2040206619829382.
● Keating, G. M. (2011). Plerixafor: a review of its use in stem-cell mobilization in patients with lymphoma or multiple myeloma. Drugs, 71(12), 1623-1647.
● McDermott, D. H., Pastrana, D. V., Calvo, K. R., Pittaluga, S., Velez, D., Cho, E., ... & Murphy, P. M. (2019). Plerixafor for the treatment of WHIM syndrome. New England Journal of Medicine, 380(2), 163-170.
Safety Advice
- ● Alcohol: Alcohol increases the risk of dehydration and might even make the side effects worse. Therefore, it is important to avoid the use of alcohol while using Plerixafor 24mg Injection (Mozifor).
- ● Driving: You should not drive or do anything else that needs a lot of alertness when using Mozifor 24mg Injection (Plerixafor), as it can cause side effects such as drowsiness or fatigue.
- ● Pregnancy: It is not recommended for pregnant women to use Mozifor 24mg Injection except where it is vital and as recommended by a doctor since it may affect the baby.
- ● Breastfeeding: A doctor may advise you to stop breastfeeding during your treatment with Plerixafor 24mg Injection (Mozifor) since it may be harmful to the baby.
- ● Kidney: There might need to be dosage adjustments of Mozifor 24mg injection in people suffering from kidney disease since it may affect the performance of the medicine.
- ● Liver: Mozifor 24mg Injection (Plerixafor) has been shown not to affect the functioning of the liver.
FAQs
1. What Mozifor 24mg Injection treat?
Mozifor 24mg Injection is not a routine treatment but collects stem cells from the bone marrow into the blood for harvesting.
2. What is the active drug composition of Mozifor 24mg Injection (Plerixafor)?
Mozifor 24mg Injection salt composition is Plerixafor which help mobilize stem cells from the bone marrow into the bloodstream for collection and transplantation.
3. Can I takePlerixafor 24mg Injection (Mozifor) with a combination of drugs?
Mozifor 24mg injection is given along with G-CSF (growth factor injections) to help increase the number of stem cells in the blood.
4. How long does it take to see complete result of Mozifor 24mg Injection (Plerixafor)?
The full effect of Mozifor 24mg Injection is usually seen within 1-2 days, but it starts working by releasing stem cells from the bone marrow into the bloodstream.
5. Is Plerixafor 24mg Injection (Mozifor) cause side effects?
Yes, the Mozifor 24mg injection causes various side effects, including nausea, headache, rash, infection, joint pain, etc. If any of the symptoms persist, visit the doctor immediately.
Marketer Details
Hetero Drugs LTD
Author Details
Written By:
Nonish Sharma
I am a medical content writer with a strong academic background in life sciences, holding an M.Sc. in Biotechnology... Read More
Reviewed By:
Vaibhav Shakya
Dr. Vaibhav Shakya, MD, is a Medical reviewer and medicine expert at Globans Pharma, with more than 9 years of experienc... Read More
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