Opdivo 40mg Injection (Nivolumab)
Opdivo 40mg Injection (Nivolumab)

Opdivo 40mg Injection (Nivolumab)

prescriptionImage Prescription Required

Manufactured By

Bristol-myers squibb pharma

Pack Of

1

Salt Composition

Nivolumab

Storage

Keep in cold place

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Opdivo 100mg Injection

Opdivo 100mg Injection

Overview

Opdivo 40mg Injection is a prescription-based anticancer medicine used in the treatment of non-small cell lung cancer, kidney cancer, head and neck cancer, melanoma, Hodgkin's disease, and liver cancer. The active ingredient of the Opdivo is nivolumab, which belongs to the drug class of PD-1 (Programmed Cell Death Protein 1) inhibitors. As a checkpoint inhibitor, nivolumab inhibits the PD-1 protein on immune T-cells, enabling your immune system to detect and destroy cancer cells. Nivolumab 40mg injection is usually given in combination with another anticancer medicine as a part of combination therapy to increase the efficacy of the treatment.

The injection is administered as an intravenous infusion by a qualified doctor in a hospital or clinical setting. The doctor determines the dosage of the Nivolumab 40mg injection according to the type of cancer, treatment regimen, age, and overall health of the patient. It should not be self-administered. Patients are advised not to change the dosage and timings prescribed by the doctors because it can cause severe side effects.

Common side effects include tiredness, weakness, nausea, decreased appetite, diarrhea, constipation, cough, skin rash, itching, and muscle or joint pain. A few patients can undergo severe side effects, including pneumonitis, hepatitis, intestinal inflammation, and kidney inflammation. Most of the Nivolumab 40mg injection side effects can leave when the body adapts to the medicine. However, report to your doctor if you experience serious side effects.

The medicine may harm an unborn baby, and pregnant women must avoid using it. Women who can become pregnant should use effective contraception during treatment. Patients must list all medicines, supplements, and herbal products that they are taking. The nivolumab 40mg injection must be used under medical oversight or medical supervision only. Attend regular tests and follow-ups to monitor the medicine response and reduce side effects. Before making any adjustments, changing the dose, or stopping the treatment, consult with your doctor to maximize the benefit.

Quick Product Facts

FieldPublication wording
Brandopdivo
Generic / Active IngredientNivolumab
Strength40
Dosage FormInjection
Manufacturer / Marketerbristol-myers squibb pharma
Pack Size1
Prescription RequiredYes
Therapeutic CategoriesCancer Medicines
UsesLiver Cancer

Uses and Indications

Head and neck cancer, kidney cancer, lung cancer, liver cancer, skin cancer

Side Effects of Opdivo 40mg Injection

Like any other chemical based medication, it also has certain common side effects. Consult your doctor, if side effects persist for longer period of time.

Common Side Effects of Nivolumab 40mg Injection are :

  • Pain in your muscles, bones, and joints Headache

  • Headache

  • Cough

  • Diarrhea

  • Nausea

  • Weakness

  • Itchy skin or rash

  • Shortness of breath

  • Decreased appetite

  • Infection in the nose or throat

  • Fever

  • Pain in your muscles, bones, and joints

 Serious Side Effects:

  • Blood In Urine

  • Severe Skin Reactions

  • Pneumonitis

  • Jaundice

  • Problem in remembering Things

Opdivo 40mg Injection Dosage and How To Take It

Nivolumab 40mg Injection is administered intravenously, either alone or with other cancer treatment therapies, depending on the cancer's type and stage. The recommended dosage is 3mg/kg every two weeks as a 60-minute infusion, usually given over 30 minutes. Patients should not self-administer; it must be injected by a doctor or trained nurse. Consult a doctor for precise dosage and timing.

Safety Advice for Opdivo 40mg Injection

  • 1. It is advisable not to consume alcohol while taking Nivolumab 40mg Injection as it can worsen the side effects. It is advised to consult your doctor for further information.
  • 2. Opdivo 40mg Injection is considered unsafe during pregnancy due to fetal harm. Please consult your doctor in such condition.
  • 3. Breast Feeding is not advisable during the Nivolumab 40mg Injection treatment Course. Consult your Doctor for more information.
  • 4. It is advisable not to drive, as you may feel dizzy after taking Nivolumab 40mg Injection.
  • 5. Share your medical history with your doctor in case of kidney disease before taking Opdivo 40mg Injection.
  • 6. Notify your doctor about any liver disease or infection before starting Nivolumab 40mg Injection course.

FAQs About Opdivo 40mg Injection

What type of cancer is treated using Nivolumab 40mg Injection?

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Nivolumab 40mg Injection is an immunotherapy based injection. It is used to treat Melanoma, Non-Small Cell Lung Cancer, Kidney Cancer, Kidney (Renal Cell) Carcinoma, Hodgkin's Lymphoma, Head and Neck Cancer as well as Liver Cancer.

Can Nivolumab 40mg Injection be given with any other medicine?

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Yes, Nivolumab 40mg Injection can be given with other chemotherapeutic drugs or injection based on cancer type and its stage to increase effectiveness.

How Nivolumab 40mg Injection is given to cancer patients?

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Nivolumab 40mg Injection is given intravenously (In veins) to cancer patients by a doctor or experienced nurse. Kindly do not try to self administer the injection.

Is Opdivo 40mg Injection advisable during Pregnancy?

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Opdivo 40mg Injection cause harm to growing fetus. Thus, it is not recommended during pregnancy for treatment.

What should I do if I experience severe side effects?

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Nivolumab 40mg Injection can cause severe side effects such as kidney problems, liver problems, blood in urine, jaundice etc. Notify your doctor immediately as it may require withholding or stopping of treatment.

References

Raedler LA. Opdivo (Nivolumab): Second PD-1 Inhibitor Receives FDA Approval for Unresectable or Metastatic Melanoma. Am Health Drug Benefits. 2015 Mar;8(Spec Feature):180-3. PMID: 26629287; PMCID: PMC4665056.

Rendon A, Rayi A. Nivolumab. [Updated 2024 Feb 28]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK567801/

Barro-Tarazona, S. S., Harshita Nadella, O. M. S., Bindiya Desai, O. M. S., & Sapasetty, A. Journal of Medical Clinical Case Reports.

Wire, W. B. US Food and Drug Administration Approves OPDIVO®(nivolumab) in Combination with CABOMETYX®(cabozantinib) as First-line Treatment for Patients with Advanced Renal Cell Carcinoma.

Marketer Details

Bristol-myers squibb pharma

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Author Details

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Written By:

Nonish Sharma

I am a medical content writer with a strong academic background in life sciences, holding an M.Sc. in Biotechnology... Read More


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Reviewed By:

Vaibhav Shakya

Dr. Vaibhav Shakya, MD, is a Medical reviewer and medicine expert at Globans Pharma, with more than 9 years of experienc... Read More

Last Updated: 08 Sept 2026 | 04:19 am (IST)

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