Laronib 25mg Capsule (Larotrectinib)
Prescription RequiredManufactured By
Eisai
Pack Of
1
Salt Composition
Larotrectinib
Storage
Keep in cold place
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Overview
Laronib 25mg Capsule is a prescription-based anticancer medicine used in the treatment of solid tumours with NTRK gene fusion. This fusion is a rare genetic disorder that can occur in tumours from different parts of the body such as the lungs, thyroid glands and intestines. The active ingredient of the Laronib is Larotrectinib which belongs to the drug class of Kinase inhibitors.
It works by blocking the action of abnormal protein produce by the NTRK gene fusion to shrink the tumor or stop its spread. Larotrectinib Capsule is usually given in combination with another anticancer medicine as a part of combination therapy to increase the efficacy of the treatment.
Indication
Kidney, Thyroid, and Liver cancer
Side Effects
The human body shows undesired symptoms after taking Laronib 25mg Capsule (Larotrectinib). Usually, they disappear with time as the body adjusts to the medicine. These side effects don't need special medical attention. It is advised to consult your doctor if these symptoms become unmanageable.
Some of the common side effects of Larotrectinib Capsule are mentioned below:
● Nausea
● Vomiting
● Diarrhea
● Constipation
● Cough
● Dizziness
● Tiredness
● abnormal liver function tests
Serious Side Effects
- ● Pale skin
- ● Cold hands and feet
- ● Unusual tiredness
- ● Feeling light-headed or short of breath
- ● Problems with speech or coordination
- ● Sores or ulcers in your mouth or on your skin
- ● Numbness, tingling, or burning pain in your hands or feet
How To Use
Larotrectinib 25mg Capsule (Laronib) is a prescription-based anticancer drug that should be administered orally. Laronib is taken orally with or without food as per the doctor's advice.
It is consumed at the same time each day for better results. It is recommended not to crush, chew, or split the capsule, take it as a whole.
Reference
● DuBois, S. G., Laetsch, T. W., Federman, N., Turpin, B. K., Albert, C. M., Nagasubramanian, R., ... & Pappo, A. S. (2018). The use of neoadjuvant larotrectinib in the management of children with locally advanced TRK fusion sarcomas. Cancer, 124(21), 4241-4247.
● Qi, C., Shen, L., Andre, T., Chung, H. C., Cannon, T. L., Garralda, E., ... & Berlin, J. (2025). Efficacy and safety of larotrectinib in patients with TRK fusion gastrointestinal cancer. European Journal of Cancer, 220, 115338.
● Laetsch, T. W., & Hawkins, D. S. (2019). Larotrectinib for the treatment of TRK fusion solid tumors. Expert Review of Anticancer Therapy, 19(1), 1-10.
● Laetsch, T. W., DuBois, S. G., Mascarenhas, L., Turpin, B., Federman, N., Albert, C. M., ... & Hawkins, D. S. (2018). Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: phase 1 results from a multicentre, open-label, phase 1/2 study. The lancet oncology, 19(5), 705-714.
● Hong, D. S., DuBois, S. G., Kummar, S., Farago, A. F., Albert, C. M., Rohrberg, K. S., ... & Drilon, A. (2020). Larotrectinib in patients with TRK fusion-positive solid tumours: a pooled analysis of three phase 1/2 clinical trials. The Lancet Oncology, 21(4), 531-540.
Safety Advice
- • Alcohol: The interaction of alcohol with this drug is still unknown. It is advisable not to consume alcohol while taking Laronibi 25mg Capsule (Larotrectinib). It is advised to consult your doctor for further information.
- • Pregnancy: Larotrectinib 25mg Capsule (Laronib) may be considered unsafe during pregnancy. Please consult your doctor in such condition.
- • Breastfeeding: Laronib 25mg Capsule (Larotrectinib) is probably not safe if you're breastfeeding. Kindly consult your doctor.
- • Driving: It is advisable not to drive or operate heavy machinery as you may feel dizzy after taking Larotrectinib 25mg Capsule (Laronib).
- • Kidney: Share your medical history with your healthcare expert in case of kidney disease before taking Laronib 25mg Capsule (Larotrectinib).
- • Liver: Inform your doctor before starting Larotrectinib 25mg Capsule (Laronib) if you have liver disease to avoid any serious side effects
FAQs
Why do doctors prescribe Laronib 25mg Capsule (Larotrectinib)?
This medicine is given to adults diagnosed with solid tumours with NTRK gene fusion.
What is the right way of taking the Laronib 25mg Capsule (Larotrectinib)?
Laronib Capsule is taken orally with or without food as per the doctor's advice. It is consumed at the same time each day for better results. It is recommended not to crush, chew, or split the capsules; take them as a whole.
What are the commonly observed side effects of Larotrectinib 25mg Capsule (Laronib)?
The most common side effects of this medicine include Diarrhea, Headache, Tiredness, Mouth sores, Muscle or joint pain, Stomach pain, and difficulty breathing. It is advised to consult your doctor if these symptoms become unmanageable.
Who should avoid taking Laronib 25mg Capsule (Larotrectinib)?
People diagnosed with severe liver, kidney and other health disorders are advised to consult their healthcare professionals before taking this medicine.
Can the Laronib Capsule (Larotrectinib) be given in combination therapy with other medications?
Yes, Laronib can be given in combination therapy with other medications to treat different kinds of cancers and to increase the effectiveness of the treatment.
Marketer Details
Eisai
Author Details
Written By:
Nonish Sharma
I am a medical content writer with a strong academic background in life sciences, holding an M.Sc. in Biotechnology... Read More
Reviewed By:
Vaibhav Shakya
Dr. Vaibhav Shakya, MD, is a Medical reviewer and medicine expert at Globans Pharma, with more than 9 years of experienc... Read More
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