Imfinzi 500mg Injection (Durvalumab)
Prescription RequiredManufactured By
Astra Zeneca
Pack Of
1
Salt Composition
Durvalumab
Storage
Keep in cold place
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Imfinzi 120mg Injection
Overview
Imfinzi 500mg Injection is an immunotherapy-based anticancer drug. It contains durvalumab as an active ingredient, which is a monoclonal antibody. It is used in the treatment of multiple cancers such as non-small cell lung cancer, biliary tract cancer, liver cancer, and endometrial cancer. This works by blocking the PD-L1 protein on cancer cells, which allows the immune system to recognize and attack these cells more effectively. Results in slowing down the growth and spread of cancer cells. Durvalumab 500mg Injection is used in combination with specific chemotherapy regimens to treat different cancer types.
The injection is administered as an intravenous infusion by a qualified doctor in a hospital or clinical setting. The doctor determines the dosage of the Durvalumab 500mg injection according to the type of cancer, treatment regimen, age, and overall health of the patient. It should not be self-administered. Patients are advised not to change the dosage and timings prescribed by the doctors because it can cause severe side effects.
Common side effects include tiredness, weakness, nausea, decreased appetite, cough, diarrhea, constipation, skin rash, and muscle or joint pain. A few patients can undergo severe side effects, including inflammation of the lungs, liver, intestines, kidneys, and other hormone-related disorders. Most of the Durvalumab 500mg injection side effects can leave when the body adapts to the medicine. However, report to your doctor if you experience serious side effects.
The medicine can harm an unborn baby and must not be used during pregnancy. Women who can become pregnant should use effective contraception during treatment. Patients must list all medicines, supplements, and herbal products that they are taking. The Durvalumab 500mg injection must be used under medical oversight or medical supervision only. Attend regular tests and follow-ups to monitor the medicine response and reduce side effects. Before making any adjustments, changing the dose, or stopping the treatment, consult with your doctor to maximize the benefit.
Indication
Non-small cell lung cancer
Side Effects
Every medicine has some side effects that manage on their own as your body gets used to the medicine, but some people may rarely experience severe side effects. In that case, the patient should contact the doctor immediately.
Some common side effects of Imfinzi 500mg Injection(Durvalumab 500mg) include:
● Cough
● Nausea
● Upper respiratory tract infection
● Rash
● Fatigue
● Hair loss
● Diarrhea
● Pneumonitis
● Breathlessness
● Itching
● Musculoskeletal (bone, muscle or joint) pain
● Abdominal pain
How To Use
The recommended dose of Imfinzi 500mg Injection(Durvalumab 500mg) may vary according to the stage of cancer, as well as age, weight, and other health factors of the patients. It should be given intravenously by a doctor or experienced nurse. Don't self- administer the injection and don't double the dose to compensate for the missed dose.
Reference
● Murakami, S. (2019). Durvalumab for the treatment of non-small cell lung cancer. Expert Review of Anticancer Therapy, 19(12), 1009-1016.
● Al-Salama, Z. T. (2021). Durvalumab: a review in extensive-stage SCLC. Targeted Oncology, 16(6), 857-864.
● Powles, T., Catto, J. W., Galsky, M. D., Al-Ahmadie, H., Meeks, J. J., Nishiyama, H., ... & Van Der Heijden, M. S. (2024). Perioperative durvalumab with neoadjuvant chemotherapy in operable bladder cancer. New England Journal of Medicine, 391(19), 1773-1786.
● Cheng, Y., Spigel, D. R., Cho, B. C., Laktionov, K. K., Fang, J., Chen, Y., ... & Senan, S. (2024). Durvalumab after chemoradiotherapy in limited-stage small-cell lung cancer. New England Journal of Medicine, 391(14), 1313-1327.
● Antonia, S. J., Villegas, A., Daniel, D., Vicente, D., Murakami, S., Hui, R., ... & Özgüroğlu, M. (2017). Durvalumab after chemoradiotherapy in stage III non–small-cell lung cancer. New England Journal of Medicine, 377(20), 1919-1929.
● Syed, Y. Y. (2017). Durvalumab: first global approval. Drugs, 77(12), 1369-1376.
● Alvarez-Argote, J., & Dasanu, C. A. (2019). Durvalumab in cancer medicine: a comprehensive review. Expert Opinion on Biological Therapy, 19(9), 927-935.
Safety Advice
- ● Alcohol: Avoid the consumption of alcohol while taking Imfinzi 500mg Injection(Durvalumab 500mg), as alcohol can decrease the effectiveness of the medicine as well as worsen the symptoms.
- ● Pregnancy: Do not take Imfinzi 500mg Injection without consulting the doctor in case of pregnancy, as it is an unsafe to take it during this period.
- ● Breastfeeding: Breastfeeding women should discuss the potential risks and benefits of the Imfinzi 500mg Injection(Durvalumab 500mg) with their healthcare provider before starting treatment.
- ● Driving: Imfinzi 500mg Injection may cause side effects such as dizziness or lack of concentration, which could affect your ability to drive. So it's better to avoid driving.
- ● Kidney: Imfinzi 500mg Injection(Durvalumab 500mg) is safe for use in kidney disease if prescribed by the doctor. No dosage adjustment is necessary for this Tablet.
- ● Liver: Imfinzi 500mg Injection(Durvalumab 500mg) is safe for use in liver disease if prescribed by the doctor. No dosage adjustment is necessary for this Tablet.
FAQs
Can a patient with kidney or liver related issue take Imfinzi 500mg Injection(Durvalumab 500mg)?
Yes, it is safe to take Imfinzi 500mg Injection in kidney or liver related conditions if prescribed by the doctor.
How to store Imfinzi 500mg Injection?
Store Imfinzi 500mg injection in the refrigerator at (2°C to 8°C) and do not freeze it. Also keep it out of reach from children.
What are the common side effects of Imfinzi 500mg Injection(Durvalumab 500mg)?
Like any other medicine Imfinzi 500mg Injection also show some side effects such as cough, nausea, upper respiratory tract infection, rash, fatigue, hair loss, diarrhea, pneumonitis, etc.
What are the uses of Imfinzi 500mg Injection?
Imfinzi 500mg Injection is prescribed to treat multiple cancers such as non-small cell lung cancer, biliary tract cancer, liver cancer, and endometrial cancer.
How does Imfinzi 500mg Injection(Durvalumab 500mg) work?
Imfinzi 500mg contains Durvalumab that is a monoclonal antibody works by blocking the PD-L1 protein on cancer cells which allows the immune system to recognize and attack these cells more effectively.
Marketer Details
Astra Zeneca
Author Details
Written By:
Nonish Sharma
I am a medical content writer with a strong academic background in life sciences, holding an M.Sc. in Biotechnology... Read More
Reviewed By:
Vaibhav Shakya
Dr. Vaibhav Shakya, MD, is a Medical reviewer and medicine expert at Globans Pharma, with more than 9 years of experienc... Read More
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