Bexinib 5mg Tablet (Axitinib)
Prescription RequiredManufactured By
Adley
Pack Of
14
Salt Composition
Axitinib
Storage
20°C–25°C / room temperature
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Overview
Bexinib 5mg Tablet contains axitinib, an oral targeted cancer medicine that is used in the treatment of kidney cancer. It works by blocking the proteins called VEGFR-1, VEGFR-2, and VEGFR-3. These proteins help cancer cells form new blood vessels that supply them with oxygen and nutrients.
By blocking these signals, the axitinib tablet can slow the growth of new blood vessels and help control advanced renal cell carcinoma (RCC). It may be used alone after previous cancer treatment or in combination with certain immunotherapy medicines as an initial treatment. Important risks include high blood pressure, bleeding, blood clots, thyroid problems, liver changes, and slower wound healing.
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Quick Product Facts
| Field | Publication wording |
|---|---|
| Brand | bexinib |
| Generic / Active Ingredient | Axitinib |
| Strength | 5 |
| Dosage Form | Tablet |
| Manufacturer / Marketer | adley |
| Pack Size | 14 |
| Prescription Required | Yes |
| Therapeutic Categories | Cancer Medicines |
| Uses | Kidney Cancer |
Uses and Indications
Axitinib 5 mg Tablet is primarily used to treat:
- Advanced renal cell carcinoma (RCC): Cancer of the kidneys which has already spread or is not being effectively treated with surgery alone.
Axitinib tablets can be used either as a monotherapy after prior systemic therapy or in combination with other drugs like pembrolizumab and avelumab in the treatment of advanced RCC. However, the treatment options depend on the type of cancer and other factors. Kidney Cancer, Immunotherapy
How Bexinib 5mg Tablet Works
This drug acts as a receptor antagonist of VEGFR-1, VEGFR-2, and VEGFR-3, which are molecules that play an important role in angiogenesis. This means that axitinib interferes with the blood supply to the tumour cells and slows down the development of the disease.
Clinical Evidence for Bexinib 5mg Tablet
AXIS: Bexinib 5mg Tablet helped patients with previously treated advanced kidney cancer live longer without the disease getting worse compared with sorafenib.
KEYNOTE-426: The combination of pembrolizumab and axitinib tablets provided better treatment outcomes than sunitinib in patients receiving first-line treatment for advanced kidney cancer.
JAVELIN Renal 101: Avelumab combined with axitinib 5mg tablet improved the time before the cancer worsened in the studied patients receiving first-line treatment for advanced kidney cancer.
Side Effects of Bexinib 5mg Tablet
With the use of the Bexinib 5mg Tablet, some individuals might suffer from adverse effects due to the influence of the drug on blood vessels and other physiological processes in the body. Some of the side effects of the medicine may include:
Common side effects
- Diarrhea
- Hypertension
- Fatigue
- Reduced appetite
- Nausea
- Weight loss
- Hoarseness
- Hand-foot syndrome
Serious side effects
- Hypertensive crisis
- Arterial/venous thromboembolism
- Serious bleeding
- GI perforation/fistula
- PRES
- Heart failure
Critical Safety Warning
HYPERTENSION + VASCULAR RISK: Bexinib 5 mg Tablets cause high blood pressure and may lead to blood vessel issues. Blood pressure should be controlled before starting the medication and must be monitored closely by the doctor. In case you experience a severe headache, neurological symptoms, chest pain, excessive bleeding, or difficult breathing, contact your healthcare provider immediately.
Bexinib 5mg Tablet Dosage and How To Take It
Clinical context | Typical labelled / protocol guidance |
Starting dose | 5 mg by mouth twice a day, usually about 12 hours apart. |
Escalation | Selected patients may increase to 7 mg twice daily and then 10 mg twice daily if well tolerated. |
Reductions | If side effects occur, the dose may be reduced to 3 mg twice a day and then 2 mg twice a day if needed. |
Strong CYP3A4/5 inhibitors | Avoid if possible; adjustment may be needed. |
Important: These are educational reference regimens. The medical specialist must individualise dose, schedule, combination, organ-function adjustment and toxicity management.
Bexinib 5mg Tablet Missed Dose
If a dose is missed or vomiting occurs after a dose, do not take an extra tablet. Take the next dose at the regular time under guidance of the doctor.
Safety Advice for Bexinib 5mg Tablet
| Category | Status | Guidance |
|---|---|---|
| Pregnancy | Avoid | Bexinib 5mg may harm the unborn baby, so pregnancy should be avoided during treatment. |
| Blood pressure | High priority | Check blood pressure regularly because axitinib tablet can cause high blood pressure. |
| Thyroid | Monitor | Thyroid problems can occur, so thyroid function may check on regular basis.. |
| Surgery | Hold as directed | Bexinib 5mg Tablet may slow wound healing, so the doctor may ask to stop it before and after surgery. |
| Driving | Caution | Avoid driving while using axitinib 5mg tablet as this may cause fatigue or dizziness which affects alertness. |
Monitoring During Bexinib 5mg Tablet Treatment
While on the Bexinib 5mg Tablet, monitoring will help the physician evaluate the effectiveness of the medicine and detect any side effects that may arise:
- Monitor blood pressure regularly.
- Check thyroid hormone levels.
- Monitor liver function whenever needed.
- Urine protein test when necessary.
- Look out for bleeding, clotting, or cardiac conditions like abnormal bleeding, chest pains, swelling, or breathing difficulties.
Bexinib 5mg Tablet Fact Box
| Parameter | Verified / publication wording |
|---|---|
| Brand | Bexinib 5mg Tablet |
| Generic | Axitinib |
| Strength | 5 mg |
| Form | Tablet |
| Manufacturer / Marketer | Adley |
| Pack | 28 tablets |
| Storage | 20°C–25°C / room temperature; confirm pack. |
| Prescription | Required |
| Self-treatment | Not appropriate; follow specialist prescription |
| Major safety theme | HYPERTENSION + VASCULAR RISK |
Bexinib 5mg Tablet Drug Interactions
| Drug / Class | Risk | What To Do |
|---|---|---|
| Strong CYP3A4/5 inhibitors | Can increase axitinib 5mg levels in the body and may increase side effects. | Avoid when possible or adjust the dose as advised by the doctor. |
| Strong CYP3A4/5 inducers | Can lower axitinib 5mg levels and may reduce its effect. | Avoid medicines such as rifampicin, carbamazepine, phenytoin, and St John’s wort when possible. |
| Other vascular-risk drugs | May make blood pressure or bleeding problems harder to manage. | Tell the doctor about all medicines being used so monitoring can be planned properly. |
FAQs About Bexinib 5mg Tablet
What cancer is Bexinib 5mg Tablet used for?
The axitinib 5mg tablet treats advanced renal cell carcinoma, a type of kidney cancer that has spread to other parts of the body or cannot be effectively treated with surgery alone.
This product is used for the treatment of various conditions.
How often is Axitinib 5mg tablet taken during the treatment?
The normal starting dose is 5 mg administered twice daily at intervals of about 12 hours, either with or without food. This dose can be adjusted by the doctor according to tolerance and response to the drug.
Can Bexinib 5mg be taken with food?
Yes, the Bexinib tablet can be taken with or without food as recommended by the healthcare professional.
Why monitor blood pressure?
High blood pressure (hypertension) is a very common and significant side effect that can occur while using the Bexinib 5 mg Tablet. Periodic monitoring of blood pressure is useful in detecting any changes at an early stage.
What if I vomit after taking Axitinib 5mg dose?
If one experiences vomiting when on treatment with Bexinib 5 mg tablets, there is no need to take the medication again. The next dose can be taken as advised once the problem subsides. It is important that you consult your physician if vomiting continues to occur.
Why check thyroid tests during the treatment?
The Bexinib 5 mg Tablet has an impact on the functioning of the thyroid gland in some people. Thyroid tests done regularly help the doctor identify such changes and treat you accordingly.
Can Axitinib 5mg tablet dose be increased?
The dose of the Bexinib 5mg Tablet can be increased in certain patients in whom the drug shows good tolerance. This decision regarding increasing the dose needs to be made by the oncologist.
References
- Chen, Y., Tortorici, M. A., Garrett, M., Hee, B., Klamerus, K. J., & Pithavala, Y. K. (2013). Clinical pharmacology of axitinib. Clinical pharmacokinetics, 52(9), 713-725. https://pubmed.ncbi.nlm.nih.gov/23677771/
- Gross-Goupil, M., Françlois, L., Quivy, A., & Ravaud, A. (2013). Axitinib: a review of its safety and efficacy in the treatment of adults with advanced renal cell carcinoma. Clinical Medicine Insights: Oncology, 7, CMO-S10594. https://pubmed.ncbi.nlm.nih.gov/26487541/
- Van Geel, R. M., Beijnen, J. H., & Schellens, J. H. (2012). Concise drug review: pazopanib and axitinib. The oncologist, 17(8), 1081-1089. https://pubmed.ncbi.nlm.nih.gov/22733795/
- Mittal, K., Wood, L. S., & Rini, B. I. (2012). Axitinib in metastatic renal cell carcinoma. Biologics in therapy, 2(1), 5. https://link.springer.com/article/10.1007/s13554-012-0005-2
- Bellesoeur, A., Carton, E., Alexandre, J., Goldwasser, F., & Huillard, O. (2017). Axitinib in the treatment of renal cell carcinoma: design, development, and place in therapy. Drug design, development and therapy, 2801-2811. https://www.dovepress.com/axitinib-in-the-treatment-of-renal-cell-carcinoma-design-development-a-peer-reviewed-fulltext-article-DDDT
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Adley
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Written By:
Nonish Sharma
I am a medical content writer with a strong academic background in life sciences, holding an M.Sc. in Biotechnology... Read More
Reviewed By:
Vaibhav Shakya
Dr. Vaibhav Shakya, MD, is a Medical reviewer and medicine expert at Globans Pharma, with more than 9 years of experienc... Read More
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