Oxabenzz 100mg/50ml Injection (Oxaliplatin Injection USP)
Prescription RequiredManufactured By
Admac life science
Pack Of
1
Salt Composition
Oxaliplatin Injection USP
Storage
Store at room temperature
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Overview
Oxabenzz 100mg/50ml Injection contains oxaliplatin, a third-generation platinum cytotoxic chemotherapy medicine used mainly in colorectal cancer. It forms platinum-DNA adducts that interfere with DNA replication and transcription. Oxaliplatin 100mg/50ml injection is most familiar as part of FOLFOX (with infusional 5-FU/leucovorin) and CAPOX/XELOX (with capecitabine). Acute cold-triggered sensory symptoms and cumulative peripheral neuropathy are characteristic toxicities. The 100 mg/50 mL vial is a preparation strength, not a standard patient dose.
Quick Product Facts
| Field | Publication wording |
|---|---|
| Brand | Oxabenzz |
| Molecule / Combination | Oxaliplatin |
| Strength / Composition | 100 mg/50 mL |
| Dosage form | IV infusion |
| Manufacturer / Marketer | Admac Life Sciences |
| Pack / Presentation | 1 injection |
| Storage | Store at room temperature |
| Prescription | Required |
Uses and Indications
Oxaliplatin 100mg/50ml injection is approved in combination with fluoropyrimidine therapy for adjuvant treatment of stage III colon cancer after complete resection and for advanced/metastatic colorectal cancer. FOLFOX and CAPOX are also used in multiple gastrointestinal-cancer protocols according to current guidelines. Dose, duration, and choice of 3 versus 6 months in adjuvant colon cancer depend on recurrence risk, regimen, and neuropathy tolerance.
How Oxabenzz 100mg/50ml Injection Works
Oxaliplatin 100mg/50ml Injection undergoes non-enzymatic conversion to reactive platinum complexes that form intra- and inter-strand DNA cross-links, blocking replication and transcription and triggering cell death.
Clinical Evidence for Oxabenzz 100mg/50ml Injection
MOSAIC: Adding oxaliplatin 100mg/50ml injection to 5-FU/leucovorin improved disease-free outcomes in resected stage III colon cancer and established FOLFOX as an adjuvant standard.
Metastatic CRC trials: Oxaliplatin-fluoropyrimidine combinations improved response and disease control in advanced colorectal cancer.
Side Effects of Oxabenzz 100mg/50ml Injection
Just like any other medication, the Oxabenzz 100mg/50ml Injection is also associated with some side effects. Most of the side effects are minor and usually go away within some time. Here are some of the symptoms, including:
Common side effects
- Cold-triggered tingling/dysesthesia
- Cumulative peripheral neuropathy
- Nausea/vomiting
- Diarrhea
- Fatigue
- Neutropenia/thrombocytopenia
Serious side effects
- Severe hypersensitivity/anaphylaxis
- Persistent sensory neuropathy
- Laryngopharyngeal dysesthesia
- Severe myelosuppression
- Hepatic sinusoidal injury
- QT prolongation/arrhythmia (rare)
Critical Safety Warning
NEUROTOXICITY/COLD WARNING: Exposure to cold air, drinks, or objects can trigger acute throat tightness, jaw spasms, and tingling after oxaliplatin. This can feel alarming but differs from true anaphylaxis; any breathing difficulty still requires immediate clinical assessment.
Oxabenzz 100mg/50ml Injection Dosage and How To Take It
Important: Dose and regimen must be prescribed by the treating specialist. Tablet/vial strength is not necessarily the patient dose. Do not start, stop, split, combine, or substitute treatment based on website information.
| Clinical situation | Dose |
|---|---|
| FOLFOX example | 85 mg/m² IV on Day 1 every 2 weeks in many regimens. |
| CAPOX example | 130 mg/m² IV on Day 1 every 3 weeks with capecitabine in common protocols. |
| Dose modification | Neuropathy, cytopenias, and organ function can require reduction or discontinuation. |
| Administration | Use compatible diluents; do not mix with chloride-containing solutions according to product instructions. |
Oxabenzz 100mg/50ml Injection Missed Dose
If an infusion is missed, contact the oncology unit. The cycle may be delayed or modified depending on blood counts and neuropathy. Do not compensate with an extra dose.
Safety Advice for Oxabenzz 100mg/50ml Injection
| Category | Status | Guidance |
|---|---|---|
| Cold exposure | Avoid after infusion | Use warm/room-temperature fluids and avoid cold objects as advised. |
| Pregnancy | Avoid | Can cause fetal harm. |
| Neuropathy | Monitor | Persistent symptoms may require dose reduction. |
| Allergy | Urgent review | Platinum hypersensitivity can become severe with repeated exposure. |
| Driving | Caution | Neuropathy/dizziness can impair driving. |
Monitoring During Oxabenzz 100mg/50ml Injection Treatment
- CBC
- Neuropathy before each cycle
- Electrolytes and renal/liver function
- Infusion hypersensitivity
- Cumulative oxaliplatin exposure
Oxabenzz 100mg/50ml Injection Fact Box
| Parameter | Verified / publication wording |
|---|---|
| Brand | Oxabenzz |
| Generic / Combination | Oxaliplatin |
| Strength | 100 mg/50 mL |
| Form | IV infusion |
| Manufacturer / Marketer | Admac Life Sciences |
| Pack | 1 injection |
| Storage | Store at room temperature |
| Major safety theme | NEUROTOXICITY/COLD WARNING |
| Prescription | Yes |
Oxabenzz 100mg/50ml Injection Drug Interactions
| Drug / Class | Risk | What To Do |
|---|---|---|
| Other neurotoxic drugs | Additive neuropathy | Monitor symptoms. |
| QT-prolonging medicines | Potential additive arrhythmia risk | Review ECG/electrolytes when appropriate. |
| Anticoagulants | Bleeding risk with thrombocytopenia | Monitor clinically.q |
| Live vaccines | Infection risk | Avoid during significant immunosuppression. |
FAQs About Oxabenzz 100mg/50ml Injection
Does one 100 mg vial equal one dose?
No. Oxaliplatin 100mg/50ml injection is usually dosed in mg/m².
Why should cold drinks be avoided while undergoing treatment with oxaliplatin 100mg/50ml injection?
Cold drinks can trigger acute nerve symptoms and throat/jaw discomfort.
What is FOLFOX?
Oxaliplatin Injection plus leucovorin and 5-FU.
Can neuropathy become permanent?
Yes. Cumulative sensory neuropathy may persist after oxaliplatin treatment.
What if throat tightness occurs after a cold drink?
Tell the oncology team; acute laryngopharyngeal dysesthesia is characteristic, but true allergy must be excluded.
Why are blood counts checked while undergoing oxaliplatin 100mg/50ml Injection treatment?
Oxaliplatin 100mg/50ml Injection can suppress bone marrow.
Can the dose of oxaliplatin 100mg/50ml injection be reduced?
Yes, especially for persistent neuropathy or cytopenias.
Who markets the Oxabenzz 100mg/50ml injection?
It is possible to verify the availability of the Oxabenzz 100mg/50ml injection by looking at our website stock status before ordering. Its availability may depend on your location and supply status.
References
- Current oxaliplatin 100mg/50ml Injection prescribing information (Eloxatin/reference). https://www.accessdata.fda.gov/drugsatfda_docs/label/2024/022160s016lbl.pdf
- André T, et al. MOSAIC. New England Journal of Medicine. https://www.nejm.org/doi/full/10.1056/NEJMoa032709
- Current NCCN colorectal-cancer guidelines. https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1428
- National Library of medicine. Oxaliplatin 100mg/50ml Injection. https://www.ncbi.nlm.nih.gov/books/NBK557690/
- Annals of oncology. Oxaliplatin: A review of preclinicals and clinical trails. https://www.annalsofoncology.org/article/S0923-7534(19)48204-5/fulltext
Marketer Details
Admac life science
Author Details
Written By:
Nonish Sharma
I am a medical content writer with a strong academic background in life sciences, holding an M.Sc. in Biotechnology... Read More
Reviewed By:
Vaibhav Shakya
Dr. Vaibhav Shakya, MD, is a Medical reviewer and medicine expert at Globans Pharma, with more than 9 years of experienc... Read More
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