Oxabenz 50mg Injection (Oxaliplatin Injection USP)
Prescription RequiredManufactured By
Admac life science
Pack Of
1
Salt Composition
Oxaliplatin Injection USP
Storage
Store at room temperature
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Overview
Oxabenz 50mg Injection contains oxaliplatin, a third-generation platinum cytotoxic chemotherapy medicine used mainly in colorectal cancer. It forms platinum-DNA adducts that interfere with DNA replication and transcription. Oxaliplatin 50mg injection is most familiar as part of FOLFOX (with infusional 5-FU/leucovorin) and CAPOX/XELOX (with capecitabine). Acute cold-triggered sensory symptoms and cumulative peripheral neuropathy are characteristic toxicities. The 50 mg/25 mL vial is a preparation strength, not a standard patient dose.
Quick Product Facts
| Field | Publication wording |
|---|---|
| Brand | Oxabenz |
| Molecule / Combination | Oxaliplatin |
| Strength / Composition | 50 mg/25 mL |
| Dosage form | IV infusion |
| Manufacturer / Marketer | Admac life science |
| Pack / Presentation | 1 injection |
| Storage | Store at room temperature |
| Prescription | Required |
Uses and Indications
Oxaliplatin 50mg injection is approved in combination with fluoropyrimidine therapy for adjuvant treatment of stage III colon cancer after complete resection and for advanced/metastatic colorectal cancer. FOLFOX and CAPOX are also used in multiple gastrointestinal-cancer protocols according to current guidelines. Dose, duration, and choice of 3 versus 6 months in adjuvant colon cancer depend on recurrence risk, regimen, and neuropathy tolerance.
How Oxabenz 50mg Injection Works
Oxaliplatin 50mg injection undergoes non-enzymatic conversion to reactive platinum complexes that form intra- and inter-strand DNA cross-links, blocking replication and transcription and triggering cell death.
Clinical Evidence for Oxabenz 50mg Injection
MOSAIC: Adding oxaliplatin 50mg injection to 5-FU/leucovorin improved disease-free outcomes in resected stage III colon cancer and established FOLFOX as an adjuvant standard.
Metastatic CRC trials: Oxaliplatin-fluoropyrimidine combinations improved response and disease control in advanced colorectal cancer.
Side Effects of Oxabenz 50mg Injection
Just like any other medication, the Oxabenz 50mg Injection is also associated with some side effects. Most of the side effects are minor and usually go away within some time. Here are some of the symptoms, including:
Common side effects
- Cold-triggered tingling/dysesthesia
- Cumulative peripheral neuropathy
- Nausea/vomiting
- Diarrhea
- Fatigue
- Neutropenia/thrombocytopenia
Serious side effects
- Severe hypersensitivity/anaphylaxis
- Persistent sensory neuropathy
- Laryngopharyngeal dysesthesia
- Severe myelosuppression
- Hepatic sinusoidal injury
- QT prolongation/arrhythmia (rare)
Critical Safety Warning
NEUROTOXICITY/COLD WARNING: Exposure to cold air, drinks, or objects can trigger acute throat tightness, jaw spasms, and tingling after an oxaliplatin 50mg injection. This can feel alarming but differs from true anaphylaxis; any breathing difficulty still requires immediate clinical assessment.
Oxabenz 50mg Injection Dosage and How To Take It
Important: Dose and regimen must be prescribed by the treating specialist. Tablet/vial strength is not necessarily the patient dose. Do not start, stop, split, combine, or substitute treatment based on website information.
| Clinical situation | Dose |
|---|---|
| FOLFOX example | 85 mg/m² IV on Day 1 every 2 weeks in many regimens. |
| CAPOX example | 130 mg/m² IV on Day 1 every 3 weeks with capecitabine in common protocols. |
| Dose modification | Neuropathy, cytopenias, and organ function can require reduction or discontinuation. |
| Administration | Use compatible diluents; do not mix with chloride-containing solutions according to product instructions. |
Oxabenz 50mg Injection Missed Dose
If an infusion is missed, contact the oncology unit. The cycle may be delayed or modified depending on blood counts and neuropathy. Do not compensate with an extra dose.
Safety Advice for Oxabenz 50mg Injection
| Category | Status | Guidance |
|---|---|---|
| Cold exposure | Avoid after infusion | Use warm/room-temperature fluids and avoid cold objects as advised. |
| Pregnancy | Avoid | Can cause fetal harm. |
| Neuropathy | Monitor | Persistent symptoms may require dose reduction. |
| Allergy | Urgent review | Platinum hypersensitivity can become severe with repeated exposure. |
| Driving | Caution | Neuropathy/dizziness can impair driving. |
Monitoring During Oxabenz 50mg Injection Treatment
- CBC
- Neuropathy before each cycle
- Electrolytes and renal/liver function
- Infusion hypersensitivity
- Cumulative oxaliplatin exposure
Oxabenz 50mg Injection Fact Box
| Parameter | Verified / publication wording |
|---|---|
| Brand | Oxabenz |
| Generic / Combination | Oxaliplatin |
| Strength | 50 mg/25 mL |
| Form | IV infusion |
| Manufacturer / Marketer | Admac life science |
| Pack | 1 injection |
| Storage | Store at room temperature |
| Major safety theme | NEUROTOXICITY/COLD WARNING |
| Prescription | Yes |
Oxabenz 50mg Injection Drug Interactions
| Drug / Class | Risk | What To Do |
|---|---|---|
| Other neurotoxic drugs | Additive neuropathy | Monitor symptoms. |
| QT-prolonging medicines | Potential additive arrhythmia risk | Review ECG/electrolytes when appropriate. |
| Anticoagulants | Bleeding risk with thrombocytopenia | Monitor clinically. |
| Live vaccines | Infection risk | Avoid during significant immunosuppression. |
FAQs About Oxabenz 50mg Injection
Does one 50 mg vial equal one dose?
No. Oxaliplatin 50mg injection is usually dosed in mg/m².
Why should cold drinks be avoided while undergoing treatment with oxaliplatin 50mg injection?
Cold drinks can trigger acute nerve symptoms and throat/jaw discomfort.
What is FOLFOX?
Oxaliplatin plus leucovorin and 5-FU.
Can neuropathy become permanent?
Yes. Cumulative sensory neuropathy may persist after oxaliplatin injection treatment.
What if throat tightness occurs after a cold drink?
Tell the oncology team; acute laryngopharyngeal dysesthesia is characteristic, but true allergy must be excluded.
Why are blood counts checked while undergoing oxaliplatin 50mg injection treatment?
Oxaliplatin 50mg injection can suppress bone marrow.
Can the dose of oxaliplatin 50mg injection be reduced?
Yes, especially for persistent neuropathy or cytopenias.
Who markets the Oxabenz 50mg injection?
It is possible to verify the availability of the Oxabenz 50mg injection by looking at our website stock status before ordering. Its availability may depend on your location and supply status.
References
- Current oxaliplatin 100mg/50ml Injection prescribing information (Eloxatin/reference). https://www.accessdata.fda.gov/drugsatfda_docs/label/2024/022160s016lbl.pdf
- André T, et al. MOSAIC. New England Journal of Medicine. https://www.nejm.org/doi/full/10.1056/NEJMoa032709
- Current NCCN colorectal-cancer guidelines. https://www.nccn.org/guidelines/guidelines-detail?category=1&id=1428
- National Library of medicine. Oxaliplatin 100mg/50ml Injection. https://www.ncbi.nlm.nih.gov/books/NBK557690/
- Annals of oncology. Oxaliplatin100mg/50ml Injection : A review of preclinicals and clinical trails. https://www.annalsofoncology.org/article/S0923-7534(19)48204-5/fulltext
Marketer Details
Admac life science
Author Details
Written By:
Nonish Sharma
I am a medical content writer with a strong academic background in life sciences, holding an M.Sc. in Biotechnology... Read More
Reviewed By:
Vaibhav Shakya
Dr. Vaibhav Shakya, MD, is a Medical reviewer and medicine expert at Globans Pharma, with more than 9 years of experienc... Read More
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