Kisqali 600mg Tablet (Ribociclib)
Prescription RequiredManufactured By
Novartis india ltd
Pack Of
21
Salt Composition
Ribociclib
Storage
Keep in cold place
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ALL SUBSTITUTES
Kryxana 200mg Tablet
Overview
Kisqali 600mg Tablet is a prescription-based anticancer medicine used in the treatment of hormone receptor-positive (HR+), HER2-negative breast cancer, including advanced or metastatic breast cancer. The active ingredient is ribociclib, which belongs to the class known as cyclin-dependent kinase (CDK) 4/6 inhibitors. This works by inhibiting the CDK4 and CDK6 proteins that help in the growth and multiplication of cancer cells. Therefore, after blocking these proteins, it can lead to decreased cancer progression and division of cancerous cells. This is usually given in combination with other anticancer or hormone therapy medicine to improve the effectiveness of treatment.
The tablet is taken orally and exactly as prescribed by the doctor. The tablet must be swallowed as whole with water and should not be crushed, chewed, or broken. It is usually taken with or without food. Ribociclib 600mg tablets are given once daily, and a doctor decides the dose and timings according to the patient's condition, combination therapy, clinical response, and stage of cancer. Patients are advised not to change the dosage because it can lead to severe side effects.
Common side effects can include low levels of white blood cells, infections, tiredness, nausea, vomiting, diarrhea, constipation, headache, loss of appetite, hair loss, and abnormal liver-function test results. Most of the Ribociclib 600mg tablet side effects can leave when the body adapts to the medicine. However, report to your doctor if you experience serious side effects.
Patients must list all medicines, supplements, and herbal products that they are taking. The Ribociclib 600mg Tablet must be used under medical oversight or medical supervision only. Attend regular tests and follow-ups to monitor the medicine response and reduce side effects. Before making any adjustments, changing the dose, or stopping the treatment, consult with your doctor to maximize the benefit.
Indication
Breast Cancer
Side Effects
The human body shows undesired symptoms after taking the Ribociclib 600mg tablet. Usually, they disappear with time as the body adjusts to the medicine. These side effects do not need special medical attention. It is advised to consult your doctor if these symptoms become unmanageable.
Common side effects
● Neutropenia
● Nausea
● Fatigue
● Diarrhea
● Vomiting
● Headache
● Alopecia
● Constipation
● Hair loss
● Skin rash
● Low white blood cell
● Infections
● Tiredness
● Low blood sugar
Serious side effects
● QT Prolongation
● Liver Toxicity
● Lung Inflammation
● Severe Skin Reactions
How To Use
Ribociclib 600mg Tablet is a prescription-based anticancer medicine. It should be taken only after consulting your healthcare doctor. This medicine is taken orally with or without food, usually once daily to maintain consistency. Swallow the tablets whole with water and do not chew or crush them.
Missed Doses
● Take the missed dose as soon as you remember but ensure that it is not close to the next scheduled dose
● If it is close to the next dose, skip the dose
● Avoid overdose of the medicine by consuming two simultaneously
● If you vomit the dose, do not consume the dose on the same day
Reference
● aedler, L. A. Kisqali (Ribociclib): Second CDK4/CDK6 Inhibitor Approved for Postmenopausal Women with HR-Positive, HER2-Negative Advanced Breast Cancer.
● Mann, J. E. (2017). Ribociclib (Kisqali®). Oncology Times, 39(16), 30.
● Hortobagyi, Gabriel N., et al. "Ribociclib as first-line therapy for HR-positive, advanced breast cancer." New England journal of medicine 375.18 (2016): 1738-1748.
● Syed, Y. Y. (2017). Ribociclib: first global approval. Drugs, 77(7), 799-807.
● Hortobagyi, Gabriel N., et al. "Overall survival with ribociclib plus letrozole in advanced breast cancer." New England Journal of Medicine 386.10 (2022): 942-950.
● Kwapisz, D. (2017). Cyclin-dependent kinase 4/6 inhibitors in breast cancer: palbociclib, ribociclib, and abemaciclib. Breast cancer research and treatment, 166(1), 41-54.
Safety Advice
- ● Alcohol: Avoid alcohol while taking the Ribociclib 600mg tablet because both the medication and alcohol are processed by the liver and can cause fatigue or nausea. Consult your doctor for further advise.
- ● Pregnancy: Ribociclib 600mg Tablet (Kisqali) may harm the unborn baby. Inform your doctor if you are pregnant or planning pregnancy. Effective contraception is recommended during treatment and for at least 3 weeks after the last dose.
- ● Breastfeeding: Do not breastfeed while taking the Ribociclib 600mg tablet and for at least 3 weeks after the last dose.
- ● Driving: Use caution while driving or operating machinery; if you experience tiredness, dizziness, or other symptoms, inform your doctor immediately.
- ● Kidney: Inform your doctor if you have kidney disease before taking Ribociclib 600mg Tablet (Kisqali), as dose adjustment may be required in severe kidney issues.
- ● Liver: Inform your doctor if you have liver disease before starting Ribociclib 600mg tablet, as dose adjustment may be required in severe liver impairment
FAQs
Does taking Ribociclib 600mg Tablet (Kisqali) cause skin rash?
Yes, Ribociclib 600mg Tablet may cause skin rash as a side effect. Consult your doctor if the rash becomes severe or persistent.
What type of cancer is treated using Ribociclib 600mg tablet ?
Kisqali 600mg Tablet is used to treat hormone receptor-positive (HR+), HER2-negative advanced or metastatic breast cancer.
Can Ribociclib 600mg tablet be used in combinations?
Yes. Kisqali is used in combination with an aromatase inhibitor or fulvestrant for advanced or metastatic breast cancer.
How is Kisqali 600mg Tablet given to cancer patients?
Kisqali 600mg is taken orally once daily for 21 consecutive days, followed by 7 days without treatment, usually as part of combination therapy.
What precautions should I take during treatment with Ribociclib 600mg tablet?
Regular blood tests, liver-function tests, and ECG monitoring may be required. Inform your doctor about other medicines you take.
Marketer Details
Novartis india ltd
Author Details
Written By:
Nonish Sharma
I am a medical content writer with a strong academic background in life sciences, holding an M.Sc. in Biotechnology... Read More
Reviewed By:
Vaibhav Shakya
Dr. Vaibhav Shakya, MD, is a Medical reviewer and medicine expert at Globans Pharma, with more than 9 years of experienc... Read More
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