Capivo 500mg Tablet (Capecitabine)
Prescription RequiredManufactured By
Medicamen
Pack Of
10
Salt Composition
Capecitabine
Storage
Keep in room temperature
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Overview
Capivo 500mg Tablet contains capecitabine, an oral fluoropyrimidine cytotoxic chemotherapy medicine converted in the body to 5-fluorouracil (5-FU). It is used in colorectal, breast, and several gastrointestinal cancer treatments. The 500 mg tablet is a strength, not a universal dose; treatment is usually calculated from body surface area and the regimen.
Hand-foot syndrome, diarrhea, mucositis, and myelosuppression are common clinically important toxicities. Severe or fatal toxicity can occur in patients with dihydropyrimidine dehydrogenase (DPD) deficiency. However, this medicine requires strict medical supervision.
Quick Product Facts
| Field | Publication wording |
|---|---|
| Brand | capivo |
| Generic / Active Ingredient | Capecitabine |
| Strength | 500 |
| Dosage Form | Tablet |
| Manufacturer / Marketer | medicamen |
| Pack Size | 10 |
| Prescription Required | Yes |
| Therapeutic Categories | Cancer Medicines |
| Uses | Pancreatic Cancer |
Uses and Indications
- Colon cancer
- Colorectal cancer
- Breast cancer
- Gastric cancer
- Pancreatic cancer
- Biliary tract cancer
Capecitabine 500mg tablets may be used after surgery, for advanced or metastatic cancer, or with other medicines depending on the cancer type. The dose and treatment schedule vary according to the disease and treatment plan.
How Capivo 500mg Tablet Works
Capecitabine tablets are converted into 5-FU in the body. The active metabolites of 5-FU block thymidylate synthase, an enzyme needed for DNA production, and can also interfere with RNA function. This disrupts the production of genetic material needed for cancer cell growth and multiplication, helping slow the growth of cancer cells.
Clinical Evidence for Capivo 500mg Tablet
X-ACT: In stage III colon cancer, capecitabine 500mg worked about as well as the older 5-FU plus leucovorin treatment after surgery.
CREATE-X: In some HER2-negative breast cancer patients who still had invasive cancer after chemotherapy before surgery, the capecitabine tablet improved treatment outcomes.
Side Effects of Capivo 500mg Tablet
Capecitabine 500mg tablet may produce side effects which range from minor to major. Monitoring regularly will help in detecting these side effects and adjusting treatment accordingly.
Common side effects
- Hand-foot syndrome
- Diarrhea
- Nausea/vomiting
- Mouth sores
- Fatigue
- Reduced appetite
- Abdominal discomfort
- Low blood counts
Serious side effects
- Severe diarrhea/dehydration
- Severe DPD-deficiency toxicity
- Cardiotoxicity/ischemia
- Severe skin reactions
- Liver toxicity
- Myelosuppression
Critical Safety Warning
DPD DEFICIENCY: If there is a severe or total lack of DPYD/DPD activity in the body, the breakdown of fluoropyrimidines might not take place in the body, which will increase the chances of having life-threatening reactions from the drug. The test for DPYD/DPD deficiency may be conducted before administering the medicine. Should unusual reactions occur, the medication should be stopped immediately.
Capivo 500mg Tablet Dosage and How To Take It
Clinical context | Typical labelled / protocol guidance |
Dose principle | The Capivo 500mg tablet dose is usually calculated according to body surface area (mg/m²). A 500 mg tablet is the tablet strength, not the standard dose for every patient. |
Traditional monotherapy | In some treatment regimens, 1,250 mg/m² is taken twice daily for 14 days, followed by 7 days without treatment. |
Modern combinations | When Capivo 500mg is used with other cancer medicines, lower doses such as about 1,000 mg/m² twice daily may be used, depending on the treatment plan. |
Renal impairment | The dose needs to be reduced in moderate kidney impairment. Capecitabine tablet is generally not recommended in severe kidney impairment. |
Important: These are only general references to be used when giving treatments. The physician will prescribe the proper dosage, frequency, interaction with other drugs, adjustment of dosage because of renal or hepatic dysfunction, and management of adverse effects depending on the patient's status.
Capivo 500mg Tablet Missed Dose
If a dose is missed, do not replace it or take extra tablets. Take the next scheduled dose at the usual time. Do not repeat a dose after vomiting.
Safety Advice for Capivo 500mg Tablet
| Category | Status | Guidance |
|---|---|---|
| DPD/DPYD | High priority | Testing or risk assessment may be considered before treatment because DPD deficiency can increase the risk of severe side effects. |
| Pregnancy | Avoid | Capecitabine tablet can harm the developing baby and should generally be avoided during pregnancy. |
| Kidney | Dose adjustment | Kidney function affects how the medicine is cleared, so the dose may need to be changed. |
| Heart | Caution | Capivo 500mg Tablet can sometimes cause heart problems, including reduced blood flow to the heart or abnormal heart rhythm. |
| Driving | Caution | Avoid driving if dizziness, weakness, or other symptoms affect alertness or ability to drive safely. |
Monitoring During Capivo 500mg Tablet Treatment
- The renal function must be evaluated periodically since it influences capecitabine 500mg clearance.
- Blood examinations have to be carried out in order to control the red blood cells, white blood cells, and platelets levels.
- The liver function and bilirubin levels have to be assessed in order to detect any potential liver disorders.
- Any manifestation like redness, swelling, pain, and peeling of hands and feet and sores in the mouth should be controlled.
- It is important to report any cases of diarrhea and dehydration.
Capivo 500mg Tablet Fact Box
| Parameter | Verified / publication wording |
|---|---|
| Brand | Capivo 500mg Tablet |
| Generic | Capecitabine |
| Strength | 500 mg |
| Form | Tablet |
| Manufacturer / Marketer | Medicamen |
| Pack | 10 x 10 tablets |
| Storage | Room temperature; verify exact pack label. |
| Prescription | Required |
| Self-treatment | Not appropriate; follow specialist prescription |
| Major safety theme | DPD DEFICIENCY |
Capivo 500mg Tablet Drug Interactions
| Drug / Class | Risk | What To Do |
|---|---|---|
| Warfarin/coumarins | Can markedly increase anticoagulant effect | Monitor INR closely and adjust treatment if needed. |
| Phenytoin | Can increase phenytoin levels | Monitor phenytoin levels and signs of toxicity. |
| Leucovorin | Can increase fluoropyrimidine toxicity | Use only as part of the prescribed treatment regimen. |
| Allopurinol | May reduce 5-FU activation/effect | Avoid when possible or use only under the doctor’s guidance. |
FAQs About Capivo 500mg Tablet
How many Capecitabine 500 mg tablets should I take?
The number depends on body-surface area and regimen; never calculate from strength alone.
Should Capivo 500mg Tablet be taken with food?
Yes, Capivo Tablet is normally taken 30 minutes after having your meal. This is because taking it after having your meal may help you adhere to the prescribed instructions for its dosage. It is important that you take this medicine according to the prescription from the doctor.
What is hand-foot syndrome?
Hand-foot syndrome is an adverse effect associated with redness, pain, swelling, burning, and peeling of the skin on the palms of the hands and soles of the feet. In other instances, the affected skin becomes sore or tender, causing discomfort in walking and using the hands.
Why is DPD important?
DPD enables the body to metabolize drugs like 5-FU and capecitabine tablet. In case of severe deficiency of DPD, there will be a buildup of these drugs in the body, which increases the chances of dangerous effects of these drugs.
What if I vomit?
It is advisable that you do not take an extra dose to compensate for the vomiting of the medicine unless instructed by your doctor. Consult your health care provider in case of persistent vomiting.
Does Capivo 500mg Tablet interact with warfarin?
Yes, Capivo 500mg Tablet may increase the action of warfarin and result in an elevated INR value. In case both medications are taken together, then INR testing is mandatory, and the dose of warfarin will be adjusted by the physician if necessary.
Is Capecitabine 500 mg tablet a chemotherapy?
Yes. Capecitabine 500 mg is a chemotherapy drug and belongs to the category of fluoropyrimidines. This drug gets converted into 5-fluorouracil (5-FU) by the body, which affects the DNA synthesis of the cancerous cells.
References
- Current Xeloda/capecitabine prescribing information https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020896s037lbl.pdf
- Twelves C, et al. X-ACT https://pubmed.ncbi.nlm.nih.gov/17241512/
- Masuda N, et al. CREATE-X. NEJM https://www.nejm.org/doi/full/10.1056/NEJMoa1612645
- Current NCCN colorectal and breast cancer guidelines https://www.nccn.org/guidelines/category_1
Marketer Details
Medicamen
Author Details
Written By:
Nonish Sharma
I am a medical content writer with a strong academic background in life sciences, holding an M.Sc. in Biotechnology... Read More
Reviewed By:
Vaibhav Shakya
Dr. Vaibhav Shakya, MD, is a Medical reviewer and medicine expert at Globans Pharma, with more than 9 years of experienc... Read More
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