Avastin 100mg Injection (Bevacizumab)
Prescription RequiredManufactured By
Roche
Pack Of
1
Salt Composition
Bevacizumab
Storage
Refrigerate 2°C–8°C; do not freeze or shake
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Overview
The Avastin 100mg Injection contains bevacizumab, a monoclonal antibody that binds vascular endothelial growth factor A (VEGF-A). By neutralizing VEGF-A, it suppresses tumor angiogenesis—the formation of new blood vessels that tumors use for oxygen and nutrients. Bevacizumab 100mg Injection is used with chemotherapy or other systemic therapy in multiple cancers, including colorectal, nonsquamous NSCLC, renal, ovarian/fallopian/peritoneal, and cervical cancers, with indication details varying by jurisdiction. The 100 mg/4 mL vial is a supply presentation; patient dosing is weight-based in mg/kg.
Quick Product Facts
| Field | Publication wording |
|---|---|
| Brand | Avastin |
| Molecule / Combination | Bevacizumab |
| Strength / Composition | 100 mg/4 mL |
| Dosage form | IV infusion |
| Manufacturer / Marketer | Roche |
| Pack / Presentation | 1 vial (4 mL) |
| Storage | Refrigerate 2°C–8°C; do not freeze or shake. |
| Prescription | Required |
Uses and Indications
Bevacizumab 100mg Injection is used in metastatic colorectal cancer with fluoropyrimidine-based chemotherapy, selected advanced nonsquamous NSCLC regimens, metastatic renal cell carcinoma in selected combinations, recurrent glioblastoma under some labels, epithelial ovarian/fallopian-tube/primary-peritoneal cancer, and persistent/recurrent/metastatic cervical cancer. It is not used as a general anticancer agent for every tumor. Histology matters—serious pulmonary hemorrhage risk is one reason it is avoided in squamous NSCLC. Surgical timing, bleeding risk, uncontrolled hypertension, proteinuria, and GI perforation risk must be assessed before treatment.
How Avastin 100mg Injection Works
Bevacizumab 100mg injection binds circulating VEGF-A and prevents activation of VEGFR-1/VEGFR-2 on endothelial cells, reducing new-vessel growth and vascular permeability.
Clinical Evidence for Avastin 100mg Injection
AVF2107g: Adding bevacizumab 100mg injection to irinotecan/5-FU/leucovorin improved survival in metastatic colorectal cancer.
ECOG 4599: Bevacizumab 100mg plus carboplatin/paclitaxel improved outcomes in selected nonsquamous NSCLC patients.
GOG-0218 / ICON7: Bevacizumab-containing strategies improved progression-free outcomes in ovarian cancer populations.
Side Effects of Avastin 100mg Injection
An Avastin 100mg injection can sometimes cause unexpected physical reactions as the body adjusts to the treatment. It is always best to discuss potential responses with a doctor.
Common side effects
- High blood pressure
- Protein in urine
- Nosebleeds
- Headache
- Fatigue
- Diarrhea
Serious side effects
- Gastrointestinal perforation/fistula
- Severe hemorrhage
- Arterial thromboembolism
- Hypertensive crisis/PRES
- Nephrotic syndrome
- Impaired wound healing
- Infusion reactions
Critical Safety Warning
GI PERFORATION, BLEEDING, AND WOUND-HEALING WARNING: bevacizumab 100mg injection can cause life-threatening GI perforation, major hemorrhage, and wound-healing complications. Treatment must be withheld around major surgery according to label guidance and not restarted until adequate healing.
Avastin 100mg Injection Dosage and How To Take It
Important: Dose and regimen must be prescribed by the treating specialist. Tablet/vial strength is not necessarily the patient dose. Do not start, stop, split, combine, or substitute treatment based on website information.
| Clinical situation | Dose |
|---|---|
| Dose principle | Weight-based; common labeled doses range from 5 to 15 mg/kg IV every 2 or 3 weeks depending on cancer/regimen. |
| Colorectal example | 5 mg/kg every 2 weeks or 7.5 mg/kg every 3 weeks in certain regimens. |
| NSCLC example | 15 mg/kg every 3 weeks with carboplatin/paclitaxel in the classic label regimen. |
| Vial strength | 100 mg/4 mL is used to prepare the calculated dose; it is not automatically one full dose. |
Avastin 100mg Injection Missed Dose
If an infusion is missed, contact the oncology unit. Do not double or shorten the interval independently. The next dose may depend on blood pressure, proteinuria, surgery, bleeding, or toxicity.
Safety Advice for Avastin 100mg Injection
| Category | Status | Guidance |
|---|---|---|
| Surgery | Hold | Follow label-defined interruption before/after major surgery. |
| Blood pressure | Control/monitor | Treat hypertension; discontinue for crisis/PRES. |
| Kidney | Monitor | Check urine protein. |
| Pregnancy | Avoid | VEGF inhibition can harm fetal development. |
| Breastfeeding | Avoid | Follow label guidance. |
| Bleeding | High caution | Review anticoagulants and tumour bleeding risk. |
Monitoring During Avastin 100mg Injection Treatment
- Blood pressure every cycle
- Urine protein
- Bleeding/thrombosis symptoms
- Wound healing/surgical dates
- Neurologic symptoms suggestive of PRES
- Infusion reactions
Avastin 100mg Injection Fact Box
| Parameter | Verified / publication wording |
|---|---|
| Brand | Avastin |
| Generic / Combination | Bevacizumab |
| Strength | 100 mg/4 mL |
| Form | IV infusion |
| Manufacturer / Marketer | Roche |
| Pack | 1 vial (4 mL) |
| Storage | Refrigerate 2°C–8°C; do not freeze or shake. |
| Major safety theme | GI PERFORATION, BLEEDING AND WOUND-HEALING WARNING |
| Prescription | Yes |
Avastin 100mg Injection Drug Interactions
| Drug / Class | Risk | What To Do |
|---|---|---|
| Anticoagulants/antiplatelets | May increase bleeding risk | Individual benefit-risk assessment and monitoring. |
| Other anti-VEGF agents | Additive toxicity | Do not duplicate therapy. |
| Myelosuppressive chemotherapy | Combination-specific toxicity | Monitor according to regimen. |
FAQs About Avastin 100mg Injection
Does one 100 mg vial equal one dose?
No. Bevacizumab 100mg Injection is dosed by body weight and regimen.
Why is blood pressure checked when undergoing bevacizumab injection treatment?
Hypertension is a common anti-VEGF toxicity and can become severe.
Why should one test urine when undergoing treatment using Avastin injection?
Proteinuria can progress to nephrotic syndrome.
Why must surgery be discussed?
Bevacizumab 100mg injection can impair wound healing.
What abdominal symptoms are urgent?
Sudden severe abdominal pain, fever, or peritonitis can signal GI perforation.
Is bevacizumab 100mg a chemotherapy medicine?
No. It is an anti-VEGF monoclonal antibody usually combined with other cancer therapy.
Can Avastin injection be used in squamous lung cancer?
It is generally avoided because of a serious pulmonary-hemorrhage risk.
Who markets the Avastin 100mg Injection?
Current stock and prescription fulfillment can be confirmed by visiting our website. Availability may vary by location, so it is advised to first check the stock before placing an order.
References
- Current bevacizumab 400mg Injection prescribing information (Avastin/reference). https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/125085s340lbl.pdf
- Hurwitz H, et al. AVF2107g. New England Journal of Medicine. https://pubmed.ncbi.nlm.nih.gov/15175435/
- Sandler A, et al. ECOG 4599. New England Journal of Medicine. https://pubmed.ncbi.nlm.nih.gov/17167137/
- G, joseph et al. Science Direct. Bevacizumab in cancer treatment. https://www.sciencedirect.com/science/article/pii/S0305737220300554
- J.pang, et al. NaturesCommunication. Efficacy of bevacizumab in cancer patients. https://www.nature.com/articles/s41467-021-21085-8
Marketer Details
Roche
Author Details
Written By:
Nonish Sharma
I am a medical content writer with a strong academic background in life sciences, holding an M.Sc. in Biotechnology... Read More
Reviewed By:
Vaibhav Shakya
Dr. Vaibhav Shakya, MD, is a Medical reviewer and medicine expert at Globans Pharma, with more than 9 years of experienc... Read More
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