Jakavi 10mg Tablet (Ruxolitinib)
Prescription RequiredManufactured By
Novartis
Pack Of
10
Salt Composition
Ruxolitinib
Storage
Keep in cold place
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ALL SUBSTITUTES
Rutinib 10mg Tablet
Overview
Jakavi 10mg Tablet is a prescription-based anticancer medicine used in the treatment of chronic idiopathic myelofibrosis (a rare type of bone marrow cancer that causes decreased blood cell production) and Polycythemia vera (blood cancer where the body produces too many red blood cells).
The active ingredient of the Jakavi is Ruxolitinib which belongs to the drug class of cyclin-dependent kinase inhibitors. It works by inhibiting the action of two enzymes known as JAK1 and JAK2, which transmit messages for regulating blood cell production and the immune response.
The problem in diseases such as myelofibrosis and polycythaemia vera is an overactivity of these messengers. Ruxolitinib Tablet is usually given in combination with another anticancer medicine as a part of combination therapy to increase the efficacy of the treatment.
Indication
Head and neck cancer, kidney cancer, lung cancer, liver cancer, skin cancer
Side Effects
The human body shows undesired symptoms after taking Jakavi 10mg Tablet (Ruxolitinib). Usually, they disappear with time as the body adjusts to the medicine. These side effects don't need special medical attention. It is advised to consult your doctor if these symptoms become unmanageable.
Common Side Effects
- Some of the common side effects of Jakavi Tablet are mentioned below:
- ● Fever
- ● Fatigue
- ● Diarrhea
- ● Hair loss
- ● Headache
- ● Confusion
- ● Depression
- ● Dehydration
- ● Constipation
- ● Abdominal Pain
- ● Nausea and vomiting
- ● Weakness & Dizziness
- ● Swelling in mouth and lips
- ● Low level of red and white blood cell
- ● Low level of platelet counts in blood
Serious Side Effects
- ● Hepatitis B
- ● Lung infection
How To Use
Ruxolitinib 10mg Tablet (Jakavi) is a prescription-based anticancer drug that should be administered orally. It is advised to take this tablet after consulting your healthcare expert.
This tablet should be swallowed as a whole with water. Don't crush, chew, or break it. It can be taken with or without food. Never skip a dose or double dose.
Missed Doses
Instructions if you miss a dose
Reference
● Verstovsek, S., Mesa, R. A., Gotlib, J., Levy, R. S., Gupta, V., DiPersio, J. F., ... & Kantarjian, H. (2015). Efficacy, safety, and survival with ruxolitinib in patients with myelofibrosis: results of a median 3-year follow-up of COMFORT-I. haematologica, 100(4), 479.
● Ajayi, S., Becker, H., Reinhardt, H., Engelhardt, M., Zeiser, R., von Bubnoff, N., & Wäsch, R. (2018). Ruxolitinib. In Small molecules in Hematology (pp. 119-132). Cham: Springer International Publishing.
● Mascarenhas, J., & Hoffman, R. (2012). Ruxolitinib: the first FDA approved therapy for the treatment of myelofibrosis. Clinical cancer research, 18(11), 3008-3014.
● Harrison, C., Kiladjian, J. J., Al-Ali, H. K., Gisslinger, H., Waltzman, R., Stalbovskaya, V., ... & Barosi, G. (2012). JAK inhibition with ruxolitinib versus best available therapy for myelofibrosis. New England Journal of Medicine, 366(9), 787-798.
● Mesa, R. A., Yasothan, U., & Kirkpatrick, P. (2012). Ruxolitinib. Nature reviews Drug discovery, 11(2), 103-104.
Safety Advice
- • Alcohol: The interaction of alcohol with this drug is still unknown. It is advisable not to consume alcohol while taking Jakavi 10mg Tablet (Ruxolitinib). It is advised to consult your doctor for further information.
- • Pregnancy: Ruxolitinib 10mg Tablet (Jakavi) may be considered unsafe during pregnancy. Please consult your doctor in such condition.
- • Breastfeeding: Jakavi 10mg Tablet (Ruxolitinib) is probably not safe if you're breastfeeding. Kindly consult your doctor.
- • Driving: It is advisable not to drive or operate heavy machinery as you may feel dizzy after taking Ruxolitinib 10mg Tablet (Jakavi).
- • Kidney: Share your medical history with your healthcare expert in case of kidney disease before taking Jakavi 10mg Tablet (Ruxolitinib).
- • Liver: Inform your doctor before starting Jakavi 10mg Tablet (Ruxolitinib) if you have liver disease to avoid any serious side effects.
FAQs
Why do doctors prescribe Ruxolitinib 10mg Tablet (Jakavi)?
This medicine is given to adults diagnosed with chronic idiopathic myelofibrosis (a rare type of bone marrow cancer that causes decreased blood cell production) and Polycythemia vera (blood cancer where the body produces too many red blood cells).
What is the right way of taking the Ruxolitinib 10mg Tablet (Jakavi)?
Ruxolitinib Tablet is taken orally with or without food as per the doctor's advice. It is consumed at the same time each day for better results. It is recommended not to crush, chew, or split the Tablets; take them as a whole.
What should be done if you feel nauseous after taking Jakavi?
Nausea and vomiting are some of the side effects seen after taking Jakavi 10mg Tablet. It is advised to consult if you're observing it continually and severely.
Is it safe to take another dose of Jakavi Tablet if lose previous dose during vomiting?
No, do not take another dose if you lost it during vomiting. It is advised just to calm down and rest properly. Don't compensate for missed doses with another day's dose.
What are the commonly observed side effects of Ruxolitinib 10mg Tablet (Jakavi)?
The most common side effects of this medicine include Diarrhea, Headache, Tiredness, Mouth sores, Muscle or joint pain, Stomach pain, and difficulty breathing. It is advised to go for regular liver function tests to examine the liver function.
Marketer Details
Novartis
Author Details
Written By:
Nonish Sharma
I am a medical content writer with a strong academic background in life sciences, holding an M.Sc. in Biotechnology... Read More
Reviewed By:
Vaibhav Shakya
Dr. Vaibhav Shakya, MD, is a Medical reviewer and medicine expert at Globans Pharma, with more than 9 years of experienc... Read More
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